Blocking Inflammation May Cause Chronic Pain

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Blocking Inflammation May Cause Chronic Pain Using anti-inflammatory drugs and steroids for pain relief may increase the odds of chronic pain, researchers at McGill University in Canada and Italy have found . Research questions traditional practices for pain relief. Inflammation occurs in normal recovery from a painful injury, and blocking inflammation with medication may result in more difficult-to-treat pain. In the study, published in the journal Science Translational Medicine, the researchers examined pain mechanisms in humans and mice. They found that neutrophils — a type of white blood cell that helps the body fight infection — played a key role in pain relief. Experimentally blocking neutrophils in mice prolonged pain to ten times the normal duration. Treating pain with anti-inflammatory drugs and steroid drugs like dexamethasone and diclofenac had the same effect, although they were effective in treating early pain. The findings are also supported by an independent analysis of half a million people in the UK, which showed that those taking anti-inflammatory drugs for pain were more likely to experience pain two to ten years later, taking acetaminophen or antidepressants. People on the drug did not have such a phenomenon. “Our study suggests that it may be time to rethink the way we treat acute pain,” said Massimo Allegri, MD, of the Policlinico of Monza Hospital in Italy and the Ensemble Hospitalier de la Cote in Switzerland. way to eliminate.”

 

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